Chewing the (Saturated) Fat / Masticare il grasso (saturo)
Chewing the (Saturated) Fat / Masticare il grasso (saturo) Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa Over the past year of doctor visits, one clinical lab value has surprised me: elevated cholesterol. It doesn’t fit with how I’ve thought of my health. I exercise five days a week, eat well, rarely eat fast food, and have no family history of premature cardiovascular disease. Plus, a handful of genetic tests found no obvious clues in my genome. Then, I became more concerned when I learned that my dad had recently been prescribed statins but soon stopped because of muscle aches, a common side effect. As I connected the dots over dinner, an unexpectedly fascinating conversation ensued about the recent excitement around next-generation cholesterol therapies, from Merck's newly approved Lipfendra (enlicitide)—a best-in-class small-molecule PCSK9 inhibitor—to Eli Lilly’s in vivo base editing program for hypercholesterolemia designed to permanen...