GENIO italiano Giuseppe Cotellessa

Compound Kills Chemotherapy-resistant Cancer Cells /  Il composto uccide le cellule tumorali resistenti alla chemioterapia Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa The administration of the compound 10580 caused human GICs (red) transplanted in mice to undergo apoptosis, a type of cell death (green). /  La somministrazione del composto 10580 ha fatto sì che GIC umani (rossi) trapiantati nei topi subissero l'apoptosi, un tipo di morte cellulare (verde).Credit: Hokkaido University A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells (GICs) has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity. Despite longstanding and earnest endeavors to develop new remedies, the prognosis of most glioblastoma patients undergoing chemotherapies and radiotherapies remains poor. Glioblastoma, a malignant glioma, has a median survival period of app...

Marco La Rosa - il sito di ricerca - 12° ANNO: IL “GENIO” ITALIANO… NONOSTANTE TUTTO…NON E’ MORTO... : All’interno intervista esclusiva al Dott. Giuseppe Cotellessa di ENEA. di : Marco La Rosa  Il “PALAZZO DELLA CIVILTA’ ITALIANA”, ...

GENIO Italiano Giuseppe Cotellessa: Optical components offer extra flexibility in ultr... : Optical components offer extra flexibility in ultrasound applications /  I componenti ottici offrono una flessibilità extra nelle applica...

New Target for Treatment of Gout /  Nuovo obiettivo per il trattamento della gotta Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa Researchers at Washington State University Health Sciences Spokane and elsewhere have identified a new therapeutic target for the treatment of gout, a common type of arthritis that causes episodes of painful and stiff joints. Published in the journal  Cellular and Molecular Immunology,  their study suggests that blocking a signaling molecule known as TAK1 can suppress inflammation caused by gout. The research lays the foundation for the development of potential new treatment strategies that could significantly improve the quality of life of millions of people around the world who suffer from the condition. In the United States alone, gout affects an estimated 8.3 million people, or about 4 percent of the population. Gout is caused by high blood levels of uric acid, a natural waste product fr...

Making Strides Towards Gene Therapy for Inherited Neurometabolic Diseases /  Fare passi avanti verso la terapia genica per le malattie neurometaboliche ereditarie Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa Researchers are making great strides toward developing gene-based strategies to treat a variety of inherited neurometabolic diseases characterized by severe neurological involvement. A review of the approaches currently under preclinical or clinical investigation is published in  Human Gene Therapy , a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.  In the article entitled  "Gene-Based Approaches to Inherited Neurometabolic Diseases,"  coauthors Valentina Poletti and Alessandra Biffi, Dana-Farber/Boston Children's Can-cer and Blood Disorders Center (Boston, MA), and University of Padova (Italy), describe the characteristics needed for a gene therapy to treat neurometabolic diseases to be...

Why Do Some Forms of Leukemia Only Affect Children? /  Perché alcune forme di leucemia colpiscono solo i bambini? Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa Each year, 2,500 pediatric cancers are diagnosed in France, with one third of cases concerning leukemia - commonly known as blood cancer. Over recent decades, research into pediatric cancer has intensified and treatments have improved, but the prognosis remains particularly unfavorable for these young patients. Acute myeloid leukemia (AML) accounts for 15% of cases of leukemia diagnosed in children and adolescents. Overall survival at 5 years is around 60%, with relapse being the most common cause of mortality. Abnormal protein fusion There are several subtypes of AML. One of the most aggressive, which is linked to treatment resistance and a particularly unfavorable prognosis, is acute megakaryoblastic leukemia (AML-M7). In their new study published in  Cancer Discov...

Marco La Rosa - il sito di ricerca - 12° ANNO: IL “GENIO” ITALIANO… NONOSTANTE TUTTO…NON E’ MORTO... : All’interno intervista esclusiva al Dott. Giuseppe Cotellessa di ENEA. di : Marco La Rosa  Il “PALAZZO DELLA CIVILTA’ ITALIANA”, ...

GENIO Italiano Giuseppe Cotellessa: Una nuova molecola per contrastare il batticuore /... : Una nuova molecola per contrastare il batticuore /  A new molecule to counteract the heartbeat Segnalato dal Dott. Giuseppe Cotellessa...

“I semi dell’uva efficaci contro i tumori”, la scoperta di un gruppo di ricercatori italiani /  "Grape seeds effective against tumors", the discovery of a group of Italian researchers Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Un recente studio ha dimostrato che nei semi degli acini d’uva di Aglianico e Falanghina ci sarebbe una particolare molecola in grado di stoppare la proliferazione di cellule di mesotelioma maligno, una rara forma di tumore che colpisce gli organi interni. Uno studio portato avanti da Enea , Cnr e l’ Università Federico II di Napoli , ha rivelato che all’interno dei semi degli acini d’uva di Aglianico e Falanghina ci sarebbero alcune molecole in grado di stoppare la proliferazione di cellule di mesotelioma maligno , una rara forma di tumore che colpisce il rivestimento di tessuto degli organi interni . Uno studio portato avanti da Enea , Cnr e l’ Università Federico II di Napoli , ha ri...

Exploring the Latest in CRISPR and Stem Cell Research /  Esplorare le ultime novità nella ricerca sulle cellule staminali e CRISPR Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa Since the gene-editing potential of CRISPR systems was realized in 2013, they have been utilized in laboratories across the world for a wide variety of applications. When this gene-editing power is harnessed with the proliferative potential of stem cells, scientists level up their understanding of cell biology, human genetics and the future potential of medicine. Thus far, the feasibility to edit stem cells using CRISPR technology has been demonstrated in two key areas: modeling and investigating human cell states and human diseases, and regenerative medicine. However, this has not been without challenges. In this article, we explore some of the latest research in these spaces and the approaches that scientists are adopting to overcome these challenges. D...