GENIO italiano Giuseppe Cotellessa

 Understanding T Cell Phenotype and Function to Enable Improved Therapeutics /  Comprensione del fenotipo e della funzione delle cellule T per consentire una migliore terapia Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Introduction  The human immune system is made up of a complex network of cells that provide continuous surveillance for anything that is non-self, such as bacteria or viruses. There are two main branches—innate and adaptive immunity—that serve different functions, but work together to overcome the different challenges the body may face. Innate immune cells are responsible for the initial response, rapidly recognizing the antigen, and generating a proinflammatory response to quickly and efficiently contain it. This includes the recruitment of macrophages, neutrophils, monocytes and dendritic cells, which in turn stimulates cells in the adaptive immunity pathway to multiply and differentiate to overcome the specific infection. This adapt

  UK’s first hydrogen train makes mainline debut /  Il primo treno a idrogeno del Regno Unito fa il suo debutto sulla linea principale Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa The HydroFLEX fuel-cell powered train. /   Il treno alimentato da celle a combustibile HydroFLEX.  Image: Birmingham University The UK’s first hydrogen powered train is due to begin mainline testing today in Warwickshire. The HydroFLEX project – developed through a collaboration between Birmingham University and industry partners – has been supported with a £750,000 grant from the Department for Transport. It follows almost two years’ development work by the university’s  Birmingham Centre for Railway Research and Education (BCRRE)   and rolling stock firm Porterbrook. The train used in the trials is a converted Class 319 dual voltage train fitted with a hydrogen fuel cell that enables it to run purely on hydrogen on non-electrified routes. Unlike diesel trains, hydrogen-powe

BARDA Balks at “Warp Speed” Funding for Oragenics COVID-19 Vaccine /  BARDA esita a finanziare "Warp Speed" per il vaccino Oragenics COVID-19 Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Oragenics acknowledged today that the Biomedical Advanced Research and Development Authority (BARDA) has rejected the company’s request to enter into talks to fund its COVID-19 vaccine candidate  Terra CoV-2  through Operation Warp Speed. “While BARDA noted the company’s submission aligned with its mission, a combination of factors, including availability of funds, precluded the agency from entering into negotiations at this time,” Oragenics said in a statement. Operation Warp Speed is the program by which President Donald Trump’s administration has committed up to a combined more than $11 billion to developers of seven COVID-19 vaccine candidates to date toward R&D, manufacturing, and distribution of their vaccines. The program aims to deliver  300 mill

  Come si cura oggi il Covid? Ecco le terapie più efficaci /   How is Covid treated today? Here are the most effective therapies Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Sono passati 7 mesi da quando si è scoperto che Sars-CoV-2 era arrivato anche in Italia. Lo sforzo per trovare una cura è enorme in tutto il mondo, ma, tra tutti i farmaci testati, attualmente solo  tre  si sono dimostrati realmente efficaci e sicuri:  remdesivir, desametasone  (con parere favorevole dell’Agenzia europea dei medicinali)  ed enoxaparina . In Italia l’Agenzia del farmaco (Aifa) ha autorizzato  45 studi clinici , la maggior parte tuttora in corso, ma che in molti casi hanno dato risultati preliminari deludenti. «L’ottimismo dei mesi scorsi si è un po’ attenuato — afferma  Filippo Drago , professore ordinario di Farmacologia e direttore dell’Unità operativa di Farmacologia clinica al Policlinico di Catania —. Le sperimentazioni vanno comunque portate a termine, ma pur