GENIO italiano Giuseppe Cotellessa

Electrogenetic Device Allows Remote Control of Cell Signaling /  Il dispositivo elettrogenetico consente il controllo remoto della segnalazione cellulare Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa The line between the Internet of Things (IoT) and the Internet of the Body (IoB) just got a little blurrier. In the IoT, everyday devices are interconnected so that they may exchange data and respond accordingly. In the IoB, networked devices include living cells, such as insulin-producing cells. Whereas IoT applications are often pedestrian, such as sensitizing an apartment’s air conditioner to the apartment dweller’s GPS information, IoB applications raise the possibility of remote-controlled therapeutics. To demonstrate the potential of the IoB, scientists based at ETH Zurich have introduced a device that uses external electric fields to trigger on-demand insulin release inside the body. When tested in mouse models of type 1 diabetes, the device wireless

On PAR: How X and Y Chromosomes Recombine During Meiosis /  Su PAR: Come i cromosomi X e Y si ricombinano durante la meiosi Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa The X and Y chromosomes make an unlikely pair. The X is large and contains thousands of genes critical for life. The Y, by contrast, is small, with only a handful of genes. Its main purpose is to provide the instructions for initiating male development and making sperm. Yet these two chromosomes must work together to meet and pair up properly during meiosis. Although this has never been fully understood, scientists at Memorial Sloan Kettering Cancer Center (MSKCC) in New York City have found an explanation. Their work is published in  Nature , in a paper titled, “ Ensuring meiotic DNA break formation in the mouse pseudoautosomal region .” During meiosis, homologous regions of DNA are swapped between chromosomes, after being deliberately broken. Homologous recombination is vastly more c

Which Drugs Are Being Used To Treat COVID-19? /   Quali farmaci vengono utilizzati per trattare COVID-19? Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa With doctors and researchers around the world searching for effective treatments for COVID-19, many drugs approved to treat other diseases are being used in hopes that they’ll be effective against the virus, a use that’s known as “off-label.” New research from the  Perelman School of Medicine at the University of Pennsylvania  catalogued every use documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments. The effort, called  COvid19 Registry of Off-label & New Agents  (CORONA), is an attempt to take an inventory of what’s being used where, as well as to spot any evidence of treatments that warrant further investigation in a randomized clinical trial. The  findings published  in  Infectious Diseases and Therap

Protein Co-Regulation Map Will Offer Better Insights on Uncharacterized Protein Functions.  The process of the ENEA RM2012A000637 patent is very useful in this application. /  La mappa di coregolamentazione delle proteine offrirà migliori approfondimenti sulle funzioni delle proteine non caratterizzate. Il procedimento del brevetto ENEA RM2012A000637 è molto utile in questa applicazione. Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Co-regulation map shows associations between human proteins. /    La mappa di coregolamentazione mostra le associazioni tra proteine umane.  [Michael Schrader - University of Exeter] Scientists reported (“ Co-regulation map of the human proteome enables identification of protein functions ”) in  Nature Biotechnology  that they have produced a co-regulation map of the human proteome, which was able to capture relationships between proteins that do not physically interact or co-localize. This will enable the prediction and as

Metabolomics Technology Navigates Oceans of Data /   La tecnologia metabolomica naviga negli oceani dei dati Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa The figure shows an overview of ReviveMed’s technology, which combines mass spectrometry instrumentation and an artificial intelligence platform. The technology can identify metabolite peaks that arise due to dysregulated molecular mechanisms, pointing to potential drug targets. /  La figura mostra una panoramica della tecnologia di ReviveMed, che combina la strumentazione di spettrometria di massa e una piattaforma di intelligenza artificiale. La tecnologia è in grado di identificare i picchi di metaboliti che sorgono a causa di meccanismi molecolari disregolati, indicando potenziali bersagli farmacologici. If workflow gaps leave your metabolomics project in the doldrums, fire up your analytical engines Even though metabolites provide the most functional information about diseases, their data has bee