GENIO italiano Giuseppe Cotellessa

Reversing Parkinson’s in Mice Achieved by Replacing Lost Neurons /   Invertire il Parkinson nei topi ottenuto sostituendo i neuroni perduti Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Left: mouse astrocytes (green) before reprogramming; Right: neurons (red) induced from mouse astrocytes after reprogramming with PTB antisense oligonucleotide treatment. /  A sinistra: astrociti di topo (verde) prima di riprogrammare; A destra: neuroni (rossi) indotti da astrociti di topo dopo riprogrammazione con trattamento oligonucleotide antisenso PTB. [UC San Diego Health Sciences] Like many other neurodegenerative diseases, there are no disease-modifying treatments available for Parkinson’s disease. Characterized by the loss of dopaminergic neurons in the substantia nigra region of the brain, most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits. Another strategy is to replace the lost neurons by creating new neurons that pr

Evil Astrocytes Emit Neuron-Killing Toxin /  Gli astrociti maligni emettono una tossina che uccide i neuroni Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Astrocytes are usually the good guys. Although they are four times as plentiful in the brain as neurons, they happily play a supporting role, serving as packing peanuts or facilitating the formation and pruning of neuronal connections. Yet good astrocytes, or resting astrocytes, can become what are known as reactive astrocytes, some of which turn evil, destroying nerve cells and likely driving many neurodegenerative diseases. The dark turn, which may be instigated by infection or trauma, has been detailed by scientists based at Stanford University Medical Center, who suggest that a broad range of brain disorders may be treatable by blocking astrocytes' metamorphosis into toxic cells, or by pharmaceutically countering the neuron-killing toxin these harmful cells almost certainly secrete. Aberrant

Marco La Rosa - il sito di ricerca - 13° ANNO: IL “GENIO” ITALIANO… NONOSTANTE TUTTO…NON E’ MORTO ! : All’interno intervista esclusiva al Dott. Giuseppe Cotellessa di ENEA. di : Marco La Rosa  Il “PALAZZO DELLA CIVILTA’ ITALIANA”, ...

GENIO Italiano Giuseppe Cotellessa: Crohn e colite ulcerosa, dare la vitamina D serve... : Crohn e colite ulcerosa, dare la  vitamina D serve a poco / Crohns  and ulcerative colitis, give the   Vitamin D is of little use ...

I polifenoli riducono gli effetti dannosi delle sigarette elettroniche / Polyphenols reduce the harmful effects of electronic cigarettes Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa La loro aggiunta al liquido delle e-cig permette di ridurre fino al 99.6% la concentrazione di molecole tossiche come la formaldeide, prodotte dalla degradazione di glicerolo e glicole propilenico. La ricerca, che prende spunto da analoghi studi nel campo della chimica degli alimenti, è stata condotta da ricercatori dell’Istituto per il sistema produzione animale in ambiente mediterraneo del Cnr, in collaborazione con le Università britanniche di Abertay, St Andrews e Nottingham pubblicata su "RSC Advances" L’utilizzo di sigarette elettroniche (e-cig) costituisce un dibattuto problema di salute pubblica perché, ad oggi, manca una completa valutazione del rischio: nonostante contengano sostanze tossiche e cancerogene in minor quantità e concentrazione rispetto al f

Pathology Post COVID-19 /  Patologia dopo COVID-19 Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa The COVID-19 pandemic has resulted in several disruptions to pathology over the last few months. Changes in caseloads and workflows are likely to continue for some time, and pressures could increase further with an influx of delayed cancer diagnoses once screening programs resume and people who have been holding off making appointments go to see their doctors. To learn more about the impact the COVID-19 pandemic is having on pathology, what the future of pathology might look like, and how digital pathology could help to ease some of the challenges, we spoke to Mark Lloyd, Founder and Executive Vice President of  Inspirata . Anna MacDonald (AM): What sort of pressures has the COVID-19 pandemic exacerbated or brought to pathologists? Mark Lloyd (ML):  The core challenges relate to  1) the work pathologists were doing pre-COVID,  2) the changes asked of the pr

Metagenomics As a Tool To Diagnose and Understand COVID-19 /   La metagenomica come strumento per diagnosticare e comprendere COVID-19 Segnalato dal Dott. Giuseppe Cotellessa /  Reported by Dr. Giuseppe Cotellessa Throughout the current COVID-19 pandemic, testing has been highlighted as a critical component of the response, enabling rapid identification and isolation of infected individuals. Most of this testing is PCR-based, detecting the presence of the SARS-CoV-2 virus only. By comparison, clinical metagenomics analyzes the whole community of microbes present in a sample. To learn about some of the advantages of this approach and how clinical metagenomics can be used as a tool to diagnose and understand pathogens such as SARS-CoV-2,  Technology Networks  recently spoke with Robert Schlaberg, co-founder and CMO of  IDbyDNA . Anna MacDonald (AM): For our readers who may be unfamiliar, please can you give us an overview of what metagenomics is? Robert Schlaberg  (RS):  Clinical metage