Advance new therapeutic opportunities in immuno-oncology with metabolism / Avanzare nuove opportunità terapeutiche in immuno-oncologia con il metabolismo
Advance new therapeutic opportunities in immuno-oncology with metabolism / Avanzare nuove opportunità terapeutiche in immuno-oncologia con il metabolismo Segnalato dal Dott. Giuseppe Cotellessa / Reported by Dr. Giuseppe Cotellessa Discover strategies to perturbate pathways and control immune cell response to advance cell therapy developments The goal of immune-cell-based therapies is to enhance the performance of native immune cells by expanding or modifying immune cells to alter relevant signaling pathways in a way that changes the cellular function. Seahorse XF technology provides critical measurements of live cells in real time, revealing the functional outcome of modulation strategies. Discover how modulation of immune cell responses via signaling, checkpoint blockade, or pathway perturbation is "functionalized" through changes in metabolic programming. CAR construct design can enhance immune cell fitness through modulation of metabolism Kawalekar et al. used the Sea